HEMOCLOT™ Thrombin Time LRT
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HEMOCLOT™ Thrombin Time LRT (CK012K) is a clotting method for the determination of Thrombin Time (TT) with ready to use liquid reagent. Manufactured by HYPHEN BioMed.
Intended Use
HEMOCLOT™ Thrombin Time LRT kit is a clotting method for the in vitro quantitative determination of Thrombin Time on human citrated plasma, using manual or automated method.
Reagents are in the liquid presentation, ready to use (LRT, Liquid reagent Technology).
Summary and Explanation
Technical The Thrombin Time is a coagulation assay measuring the time to convert fibrinogen to fibrin.
Clinical The Thrombin Time is a screening test to assess abnormalities of fibrinogen and to detect inhibitors against thrombin or fibrin. It can be useful for the evaluation of Disseminated Intravascular Coagulation (DIC) and liver disease.
A prolonged Thrombin Time can result from:
- Presence of antithrombin activity induced by therapy (eg Heparin, hirudin, argatroban, dabigatran).
- Presence of high concentrations of Fibrin/Fibrinogen degradation products.
- Qualitative (dysfibrinogenemia) or quantitative abnormalities of Fibrinogen (deficiency, DIC, fibrinolysis, hepatic disorders including cirrhosis).
The Thrombin Time is normal in presence of a Factor XIII deficiency.
Principle
The HEMOCLOT™ Thrombin Time LRT kit is a reagent for Thrombin Time (TT). It measures the clotting time (CT) induced by a controlled and constant amount of bovine thrombin, in presence of calcium, on citrated plasma. The time required for the formation of a stable clot is measured in seconds.
Reagents
R Bovine Thrombin, and Calcium, liquid form. Contains BSA, preservatives and stabilizers.
6 vials of 5 mL.
The bovine Thrombin concentration (about 1.0 NIH/mL) can vary from lot to lot and is adjusted for each lot in order to offer a high sensitivity of Thrombin Time assay to low concentrations of Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH).
UKCA
