Prof Greinacher’s recent work on highly immunogenic complexes of negatively charged heparin and positively charged platelet factor 4 has identified potential PF4 binding structures on Gram negative bacteria. Preimmunisation of patients by PF4/bacteria complexes may help to explain the unusually early ant-PF4/heparin IgG response during heparin treatment, i.e. this is a secondary immune response.
We have available, 2 versions of Zymutest HIA IgG assay, a 96 well and 32 well specific IgG antibodies to Heparin/PF4 and protamine sulphate
We also heard a very lively presentation from Professor Samama Paris,
The Biophen DTI and DiXaI chromogenic assays and the Hemoclot TI can be used with the plasma based calibrators and controls for Dabigatran and Rivaroxaban