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Bio-Synthesis Inc. Introduces “BNA-NC”

The third generation of 2′,4′-BNA-NC contains a 6-membered ring with a N-O bond between the 2′-hydroxyl and the 4′-carbon of the ribose moiety. It exhibits very strong binding affinity to complementary single stranded RNA, DNA, and double stranded DNA with a highly sequence-selective mode. In particular, the binding ability to complementary RNA is significantly high. BNA-NC also possesses great stability due to its nuclease resistant properties. (Follow the full Press Release here.)

BNA Features

  • Improved hybridization selectivity and specificity
  • Increased thermal duplex stability
  • Enhanced allelic discrimination
  • High biological stability to nuclease and protease
  • Superior antisense inhibition and potency
  • Flexible probe designs regardless of GC content
  • Easily adaptable to many DNA or RNA detection system
Applications

  • Antigene inhibition
  • Inhibition of RNA function
  • Real-time/ qPCR
  • SNP detection /allele specific PCR
  • In situ hybridization
  • DNAzymes and Ribozymes
  • Biosensor and more

Read more—http://www.biosyn.com/News.aspx

 

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