Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid (Special Terms Apply*)

*Special Terms: Please see product specification details below and our Ordering page for details.

Adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) is an important virulence factor for Bordetella pertussis which targets sentinel cells of the host’s innate immune defense. It penetrates a variety of immune cells and, when activated by calmodulin, catalyzes conversion of cellular ATP to cyclic AMP, interfering with cell signaling and with the anti-bacterial activity of phagocytes. This toxin acts on phagocytes by limiting their ability to produce oxidative burst and kill bacteria through complement or antibodies. Non-enzymatic ACT toxoid (CyaA-AC-) is a potent protective antigen and adjuvant that boosts immunogenicity of co-administered B. pertussis antigens and improves the efficacy of acellular pertussis vaccines in mice.