Fasciola ES Western Blot IgG (96T)
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Fasciola ES Western Blot IgG (96T) (FAS ES-WB96G) is a single use qualitative test of serological IgG diagnosis by Immunoblot Assay of fasciolosis intended for confirmatory testing of a positive or equivocal result obtained through classic screening tests. Kit of 96 tests.
Fasciolosis (hepatic distomatosis) is a zoonosis due to the presence in the organism of trematode worms, commonly known as liver flukes. The species of the Fasciola genus have different life cycles involving different hosts and have a various geographical distribution. Among them, Fasciola hepatica, main agent of fasciolosis is also the most commonly found species, and present worldwide. The adult fluke lives in biliary canals of a wide proportion of mammalians, such as cattle and sheep, while humans are accidental hosts. Adults release a large number of eggs through hosts feces. They hatch in water, releasing a ciliated embryo (myracidium) that penetrates into a snail of the Lymnaea genus. The parasite multiplies into the snail before leaving it as a mobile larva (cercariae) which encysts on water plants (metacercariae). Final host gets infected by ingestion of contaminated plants (water cress, dandelion, chicory…). For the other species of flukes, contamination can occur by ingestion of undercooked fresh water fish or shellfish (Dietrich et al., 2015).
FASCIOLA ES Western Blot IgG TEST
The Western Blot technique has been widely used in recent years for the diagnosis of fasciolosis. It allows the diminution of cross-reaction risks compared to other serological techniques (Mezo et al., 2003).
The Haute Autorité de Santé (HAS) in France as well as the American Center for Disease Control (CDC) recommend the immunoblot for the confirmation of serodiagnoses (Argumentaire HAS, 2018, DPDx CDC, Fasciolasis, 2019). Serological follow-up is indicated in case of diagnosis during the acute invasion phase of the disease.
In order to answer the demand, LDBIO Diagnostics developed a reliable test based on the Western Blot technique. Associated with highly sensitive natural ES antigens, the FASCIOLA ES Western Blot IgG test is a robust confirmation technique of classical screening tests for the diagnosis of fasciolosis.
Each kit is composed of sensitized and precut strips, the ready-to-use liquid reagents, and the positive control serum.
