Coatest® APC Resistance-V-S (Genotype)
We're always working hard to give our customers as much information on products and the best price possible. If you need any assistance or would like a quote please contact us and we will be happy to help
Coatest® APC Resistance-V-S (Genotype) (82313863) is an APTT-based kit for screening of Factor V (FV)-related APC resistance (40 – 80 determinations). Manufactured by Chromogenix.
An APTT-based kit for screening of factor V-related APC resistance. High discrimination between genotypes with 100% sensitivity for FV:Q506. Reduces need for PCR determination and applicable to anticoagulant treated patients.The high sensitivity and specificity of the test for the factor V:Q506 mutation is obtained by prediluting the sample plasma with an excess of V-DEF Plasma. The test design makes it possible to discriminate between heterozygous and homozygous factor V genotypes. It also allows for analysis of plasma from patients on heparin or oral anticoagulant therapy.
One volume of plasma is prediluted with four volumes of V-DEF Plasma. The dilution is then incubated with the APTT reagent for a standard period of time. Coagulation is triggered by the addition of CaCl2 in the absence and presence of exogenous APC and the time for clot formation is recorded.