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Virus-like particles for vaccine R&D and diagnostic assays
Virus-like particles (VLPs) are self-assembled protein nanoparticles that closely resemble viruses, but contain no viral genetic material and are replication-deficient. First discovered in 1968 in sera of patients infected with Hepatitis B virus, VLPs have since become vital tools for scientific and translational research in biology and medicine. The utility of VLP technology has expanded […]
Chromogenic Substrates in Haemostasis
Chromogenic substrates are small synthetic peptides which mimic the natural substrate of the enzyme and have a detector chromophore, typically para-nitroaniline (pNA), attached to the cleavage site. Enzymatic cleavage releases pNA and results in a colour change, which can be followed spectrophotometrically and is proportional to the activity of the enzyme. The concept of chromogenic […]
Pathogen Diagnostics Tips & Tricks
OPTIMAL ASSAY SELECTION FOR DIAGNOSTIC PARASITOLOGY & MYCOLOGY Conventional diagnostic methods (e.g., faecal egg count, blood smear examinations) rely on the presence of parasite, eggs, fungus, or spores in the patient sample and are often time consuming, subjective, and demand high expertise. Serology methods are gradually becoming a new standard for clinical diagnostics. They harness […]
