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New Products from Bio-Synthesis: GLYCOPEPTIDES

14 December 2012


Advanced glycation end products (AGEs) are a class of compounds formed from non-enzymatic reactions of proteins with glucose, mannose and other reducing sugars. Prolonged exposure of proteins to glucose as in the case of diabetics have been attributed to increased AGEs formation.AGEs are formed when a sugar reacts with an amino group of a protein, to form a Schiff base which rearranges into an Amadori product as in the case of hemoglobin A1c.

As a result, N-glycated peptides have received high priority to serve as biomarkers for diagnosis and prognosis of diabetes by monitoring progress and evaluating the efficacy of its therapy.

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