CEPHEN™ 1 LS
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CEPHEN™ 1 LS (CK521K) is a liquid reagent, ready to use, for the determination of Activated Partial Thromboplastin Time (APTT) on citrated human plasma, using a manual, semi automated or automated clotting method. Low sensitivity to Lupus Anticoagulant. Manufactured by HYPHEN BioMed.
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Intended Use
The CEPHEN™ LS kits are proposed for the in vitro quantitative determination of activated Partial Thromboplastin Time (aPTT) on citrated human plasma, using manual or automated clotting method with liquid reagents ready to use (LRT, Liquid reagent Technology).
This reagent offers a good sensitivity to the presence of Lupus Anticoagulant (LA), and can be used in combination with a low sensitivity reagent (CEPHEN™) for the exploration of LA.
Summary and Explanation
Technical: Measurement of the plasma recalcification time, in presence of the standardized aPTT reagent (phospholipids and activator), on human citrated plasma, as a global screening test to explore the activity of the coagulation Factors (II, V, X, VIII: C, IX, XI, XII) and Fibrinogen.
Clinical: The aPTT is a screening test to assess:
- Some anticoagulant therapies.
- Abnormalities of intrinsic coagulation pathway factors.
- Abnormalities or acquired deficiencies due to an excessive consumption of the coagulation factors, hepatic disorders…
- Coagulation inhibitors such as LA or auto-antibodies against coagulation factors.
CEPHEN™ LS has a higher sensitivity to LA than CEPHEN™.
Principle
CEPHEN™ LS is an activated Partial Thromboplastin Time (aPTT) reagent.
Activation of intrinsic pathway on citrated plasma is induced by activator (micronized silica) and mixture of vegetable soybean and synthetic phospholipids, and the clotting time (CT) is measured in presence of calcium.
UKCA
