Coatest® APC Resistance-V (Genotype)
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Coatest® APC Resistance-V (Genotype) (82312063) is an APTT-based kit for screening of Factor V (FV)-related APC resistance (80 – 160 determinations). Manufactured by Chromogenix.
An APTT-based kit for screening of factor V-related APC resistance. High discrimination between genotypes with 100% sensitivity for FV:Q506. Reduces need for PCR determination and applicable to anticoagulant treated patients.The high sensitivity and specificity of the test for the factor V:Q506 mutation is obtained by prediluting the sample plasma with an excess of V-DEF Plasma. The test design makes it possible to discriminate between heterozygous and homozygous factor V genotypes. It also allows for analysis of plasma from patients on heparin or oral anticoagulant therapy.
One volume of plasma is prediluted with four volumes of V-DEF Plasma. The dilution is then incubated with the APTT reagent for a standard period of time. Coagulation is triggered by the addition of CaCl2 in the absence and presence of exogenous APC and the time for clot formation is recorded.