| Quadratech
News
updated
1/2010 |
|
Zymuphen
MP-Activity
HYPHEN
BioMed presents the very first quantitative
assay for measurement of microparticles' procoagulant activity in citrated
plasma.
- Highly sensitive
assay for many clinical applications, for diagnosis, prognosis and therapy
monitoring
- Ready to use, optimised,
easy to perform, fully documented
- Microplate format,
disposable
Direct
Thrombin Inhibitors
Two new
assays from Hyphen Biomed are now available for the determination
of direct thrombin inhibitors, e.g. hirudin, lepirudin, argatroban, dabigatran
etc., in human plasma.
Hemoclot Thrombin Inhibitors: is
a clot based assay for the quantitative measurement of hiridin and other
direct thrombin inhibitors in plasma by their direct activity to thrombin.
Biophen DTI: is
a chromogenic, quantitative assay for measuring the anit-IIa activity
of hirudin and other direct thrombin inhibitors (except argatroban). It
is an ideal aid for monitoring therapy and adjusting drug dosage.
Both
assays are fully automatable and offer linear dose response curves even
at therapeutic doses >0.1ug/ml. In addition, the assays do not suffer
from prothrombin or fibrinogen interference.
Biophen
FVIII:C
- A unique combination
of reagents for chromogenic measurement of Factor VIII:C in plasma or
concentrates.
- Utilising human
FX, human FIXa and human Thrombin and showing good agreement with clotting
based assays.
- Excellent batch
to batch reproducibility due to highly consistent manufacturing process.
- All reagents split
into multiple vials allowing for smaller batch use and better kit economy.
Hemoclot
Quanti V-L
Hyphen Biomed have
developed a unique clotting method for the quantitative measurement of
Factor V-L (Factor V Leiden) concentration in citrated plasma, by its
resistance to the action of Activated Protein C (APC). It is suitable
for diagnosing patients carrying the R506Q mutation or any FV mutant resistance
to APC.
Hemoclot Quanti.V-L is a fully automatable test which uses a calibration
curve to give reliable and easy to interpret results. Cost and time efficiency
is also realised as only one clotting test is required per patient.
Publications
for Haemostasis:
Heparin-induced
thrombocytopenia
A. Greinacher. Journal of Thrombosis and Haemostasis 2009; 7, Supp
1, 9-12 pdf
Mechanisms involved in heparin-induced thrombocytopenia and associated
thrombosis
Ann Marie Vissac, Jean Amiral.
Seminars in Thrombosis and Hemostasis 2008, 34, Supp 1, 18-26
download
Direct Thrombin Inhibitors Marcello Di Nisio, Saskia
Middeldorp, Harry Buller. New England Journal of Medicine 2005; 353,
1028 pdf
Guideline: Investigation and management of heritable thrombophilia
Isobel D Walker, M. Greaves, F.E. Preston on behalf of the Haemostasis
and Thrombosis Task Force, British Committee for Standards in Haematology.
British Journal of Haematology 2001; 114, 512-528
Standardization of the APC Resistance Test. Effects of Normalization
of Results by Means of Pooled Normal Plasma
Armando Tripodi, Veena Chantarangkul, Barbara Negri, Pier Mannuccio
Mannucci.
Thrombosis and Haemostasis 1998; 79, 564-566.
ISTH XXII Congress, July 2009 Abstracts:
New assays for measuring direct thrombin inhibitors in plasma. JJ
Amiral, AM Vissac, M Peyrafitte.
download
Can we improve clinical specificity for HIT immunoassays?
JJ Amiral, AM Vissac. download
Pseudo-HIT associated with antibodies to protamine sulfate.
JJ Amiral, AM Vissac.
download
ISTH
Sub Committee minutes
Qualitative
Measurement of Urine Myoglobin in Crush Injury
After a recent evaluation we can now offer a modified version
of our serum myoglobin rapid assay palette test. Samples pre-diluted and
run as in the original serum method have shown to be as good a predictor
for internal crush injury as a more laborious haemoglobin/filter method.
After pre-dilution the assay is as convenient and fast (10-15 minutes)
as a one-step pregnancy test.
Based on colloidal gold immunochromatography results are read as pink
bars; 1 for negative and 2 for positive.
Each test is individually sealed in a foil pouch with 20 per pack.
Quadratech
Ltd
PO Box 167
Epsom
Surrey KT18 7YL
tel: +44(0)20 87867811
fax: +44(0)20 87867822
email: quadratech@btinternet.com |
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